Article

Promyelocytic Leukemia Protein Promotes Neuroprotection in a mouse model of Alzheimer’s Disease by Modulating the Microglial Inflammatory Response

2026-01-20

Abstract excerpt

<title>Abstract</title> <p> Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by amyloid deposition, neurofibrillary tangles, neuroinflammation and synaptic dysfunction. The Promyelocytic leukemia protein (PML) and the cognate nuclear bodies (PML-NB) have emerged as critical regulators of the nervous system, regulating neocortex development, neuronal survival, protei...

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Literature Corpus work: 42510478-f82b-58da-8bf1-87d21ccdce2c
DOI: 10.21203/rs.3.rs-8584272/v1

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