Article

Assessing genetic overlap and causality between blood plasma proteins and Alzheimer’s Disease

2021-04-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Blood plasma proteins are modifiable and have been associated with Alzheimer’s disease (AD), but understanding which proteins are on the causal pathway remains challenging. <h4>Objective</h4> Investigate the genetic overlap between candidate proteins and AD using polygenic risk scores (PRS) and interrogate their causal relationship using bi-directional Mendelian Randomization...

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Literature Corpus work: 4e7881dd-e976-56bb-a976-353627c22aae
DOI: 10.1101/2021.04.21.21255751

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