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Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults.

GeroScience - 1 Apr 2025

Beydoun May A, Beydoun Hind A, Li Zhiguang, Hu Yi-Han, Noren Hooten Nicole, Ding Jun, Hossain Sharmin, Maino Vieytes Christian A, Launer Lenore J, Evans Michele K, Zonderman Alan B

Abstract excerpt

Alzheimer's Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk's relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006-2010) were followed-up for ≤ 15 y for dementia incidence. Plasma proteomics were performed on a sub-sample of UK Biobank participants (k = 1,463 plasma proteins). AD...

Topics

Humans
Alzheimer Disease
Female
United Kingdom
Male
Aged
Incidence
Proteome
Middle Aged
Dementia
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Aged, 80 and over

Proportional Hazards Models

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 39586964
DOI: 10.1007/s11357-024-01413-8
PMCID: PMC11978584

Genes

GFAP
BRK1
PLA2G7
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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