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Article

Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults.

GeroScience - 1 Apr 2025

Beydoun May A, Beydoun Hind A, Li Zhiguang, Hu Yi-Han, Noren Hooten Nicole, Ding Jun, Hossain Sharmin, Maino Vieytes Christian A, Launer Lenore J, Evans Michele K, Zonderman Alan B

Abstract excerpt

Alzheimer's Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk's relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006-2010) were followed-up for ≤ 15 y for dementia incidence. Plasma proteomics were performed on a sub-sample of UK Biobank participants (k = 1,463 plasma proteins). AD...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39586964
DOI: 10.1007/s11357-024-01413-8
PMCID: PMC11978584

Genes

GFAP
BRK1
PLA2G7
TREM2

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