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Article

Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data.

Journal of translational medicine - 6 Mar 2025

Zhan Hui, Cammann Davis, Cummings Jeffrey L, Dong Xianjun, Chen Jingchun

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the main cause of dementia with few effective therapies. We aimed to identify potential plasma biomarkers or drug targets for AD by investigating the causal association between plasma proteins and AD by integrating comprehensive Mendelian randomization (MR) and multi-omics data. METHODS: Using two-sample MR, cis protein quantitative trait loci (cis-pQTLs) for 1,916 plasma...

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Identifiers

PMID: 40050982
DOI: 10.1186/s12967-025-06317-5
PMCID: PMC11884171

Genes

GRN
BLNK
CD2AP
PILRA
PILRB

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