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Article

Causal Effects of Plasma Haptoglobin Levels on Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Lin Yijia, Hu Tingjun, Cheng Lizhen, Chen Yixin, Li Wei, Guo Qihao, Miao Ya

Abstract excerpt

BACKGROUND: A connection between plasma levels of haptoglobin (Hp) and Alzheimer's disease (AD) has been shown in several observational studies. It is debatable, nonetheless, how the two are related causally. OBJECTIVE: To establish the causal relationship between Hp and AD using a two-sample Mendelian randomization (MR) study. METHODS: From the extensive genome-wide association studies and FinnGen dataset,...

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PMID: 37522206
DOI: 10.3233/JAD-230159

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