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Therapeutic targets for Alzheimer's disease: Proteome-wide Mendelian randomization and colocalization analyses

2 Jun 2025

Abstract excerpt

BackgroundAlzheimer's disease (AD) is a major neurodegenerative disorder with limited treatment options.ObjectiveThis study aimed to identify novel therapeutic targets for AD using proteome-wide Mendelian randomization (MR) and colocalization analyses.MethodsWe conducted a large-scale, proteome-wide MR analysis using data from two extensive genome-wide association studies (GWASs) of plasma proteins: the UK...

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PMID: 40452368
DOI: 10.1177/13872877251344572

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