Article

A <i>MSTN</i> <sup>Del273C</sup> mutation with <i>FGF5</i> knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

2023-03-09

Abstract excerpt

Mutations in the well-known Myostatin ( MSTN ) produce a “double-muscle” phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at different loci of the MSTN often produce a variety of different phenotypes. In the current study, we increased the delivery ratio of Cas9 mRNA to sgRNA from the traditional 1:2 to 1:1...

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Literature Corpus work: 4e596614-fd6a-5d9f-b52c-6fe9b540616c
DOI: 10.1101/2023.03.09.531872

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