Article
Mutation in myostatin 3'UTR promotes C2C12 myoblast proliferation and differentiation by blocking the translation of MSTN.
International journal of biological macromolecules - 1 Jul 2020
Ge Luxing, Dong Xiangchen, Gong Xutong, Kang Jian, Zhang Yong, Quan Fusheng
Abstract excerpt
The point mutation in myostatin (MSTN) can produce the Texel sheep double muscle phenotype. However, whether other species have the same mode of action as MSTN and whether breeding materials can be obtained through cross-species genetic editing remain unclear. The mutation in the mouse MSTN 3'UTR could create a target site for mmu-miR-1/206, as verified by the dual luciferase reporter system. A C2C12 cell model...
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