Article

A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

2024-10-04

Abstract excerpt

Mutations in the well-known Myostatin ( MSTN ) produce a ‘double-muscle’ phenotype, which makes it commercially invaluable for improving livestock meat production and providing high-quality protein for humans. However, mutations at different loci of the MSTN often produce a variety of different phenotypes. In the current study, we increased the delivery ratio of Cas9 mRNA to sgRNA from the traditional 1:2 to 1:10,...

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Literature Corpus work: 34a0a063-1297-5137-a83d-3971d23d5300
DOI: 10.7554/elife.86827.3

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