Article
Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system.
Scientific reports - 15 Jul 2016
Guo Rihong, Wan Yongjie, Xu Dan, Cui Libin, Deng Mingtian, Zhang Guomin, Jia Ruoxin, Zhou Wenjun, Wang Zhen, Deng Kaiping, Huang Mingrui, Wang Feng, Zhang Yanli
Abstract excerpt
Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then analyzed the changes in their phenotypes to answer this question. We efficiently generated 24 Mstn KO...
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