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Article

Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9.

Scientific reports - 26 Apr 2016

Lv Qingyan, Yuan Lin, Deng Jichao, Chen Mao, Wang Yong, Zeng Jian, Li Zhanjun, Lai Liangxue

Abstract excerpt

CRISPR/Cas9 has been widely used in generating site-specific genetically modified animal models. Myostatin (MSTN) is a negative regulator of muscle mass, related to muscle growth and differentiation. The knockout of MSTN with the desired phenotype of double muscle has been successfully generated in mice, goats, pigs and cattle, but not in rabbits. In this study, the MSTN knockout (KO) rabbits were generated by...

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Source

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Identifiers

PMID: 27113799
DOI: 10.1038/srep25029
PMCID: PMC4844959

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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