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Article

Efficient and Specific Generation of MSTN-Edited Hu Sheep Using C-CRISPR.

Genes - 2 Jun 2023

Guo Rihong, Wang Huili, Meng Chunhua, Gui Hongbing, Li Yinxia, Chen Fang, Zhang Chenjian, Zhang Han, Ding Qiang, Zhang Jianli, Zhang Jun, Qian Yong, Zhong Jifeng, Cao Shaoxian

Abstract excerpt

Hu sheep, an indigenous breed in China known for its high fecundity, are being studied to improve their growth and carcass traits. MSTN is a negative regulator of muscle development, and its inactivation results in muscularity. The C-CRISPR system, utilizing multiple neighboring sgRNAs targeting a key exon, has been successfully used to generate genes for complete knockout (KO) monkeys and mice in one step. In...

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Identifiers

PMID: 37372396
DOI: 10.3390/genes14061216
PMCID: PMC10298037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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