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Article

The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore.

The EMBO journal - 2 Jun 2003

Goshima Gohta, Iwasaki Osamu, Obuse Chikashi, Yanagida Mitsuhiro

Abstract excerpt

Mis12 is a kinetochore protein essential for equal chromosome segregation and is evolutionarily conserved from yeast to human. In this study, we report the isolation and characterization of suppressors of the mis12 mutant in fission yeast. Our results indicate that Mis12 is negatively regulated by a highly conserved protein phosphatase Ppe1 (scSit4/dmPPV/hPP6) or its bound partner Ekc1 (scSAP), and it is...

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Identifiers

PMID: 12773390
DOI: 10.1093/emboj/cdg266
PMCID: PMC156763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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