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Article

Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.

Cell reports - 11 Jul 2013

Matos Joao, Blanco Miguel G, West Stephen C

Abstract excerpt

Homologous recombination leads to the formation of DNA joint molecules (JMs) that must be resolved to allow chromosome segregation, but how resolution is temporally coupled with chromosome segregation is unknown. Here, we have analyzed the role of the cell-cycle kinases Cdk and Cdc5 in coordinating these events through their involvement in the phosphoregulation of the Mus81-Mms4 nuclease. By identifying CDC5 and...

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Identifiers

PMID: 23810555
DOI: 10.1016/j.celrep.2013.05.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.PMID 23810555Read ↗

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Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Semantic proximity Read ↗

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