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Article

CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.

Current biology : CB - 22 Aug 2006

Aoki Keita, Nakaseko Yukinobu, Kinoshita Kazuhisa, Goshima Gohta, Yanagida Mitsuhiro

Abstract excerpt

Shortened kinetochore microtubules take separated chromatids to the opposing spindle poles in anaphase. Fission yeast Dis1 belongs to the Dis1/XMAP215/TOG family that is required for proper microtubule dynamics. Here, we report that Dis1is regulated by Cdc2 phosphorylation and that this mitotic phosphorylation ensures the fidelity of chromosome segregation. Whereas mutants Dis1(6A) and Dis1(6E) that substitute...

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Identifiers

PMID: 16920624
DOI: 10.1016/j.cub.2006.06.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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