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Article

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.

Nature cell biology - 1 Jan 2007

Woodbury Erika L, Morgan David O

Abstract excerpt

The fidelity of chromosome segregation depends on proper regulation of mitotic spindle behaviour. In anaphase, spindle stability is promoted by the dephosphorylation of cyclin-dependent kinase (Cdk) substrates, which results from Cdk inactivation and phosphatase activation. Few of the critical Cdk targets have been identified. Here, we identify the budding-yeast protein Fin1 (ref. 7) as a spindle-stabilizing...

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Source

Identifiers

PMID: 17173039
DOI: 10.1038/ncb1523

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.PMID 17173039Read ↗

The role of self-association in Fin1 function on the mitotic spindle.Semantic proximity Read ↗

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.Semantic proximity Read ↗

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.Semantic proximity Read ↗

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase.Semantic proximity Read ↗

The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFsSemantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis.Semantic proximity Read ↗

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.Semantic proximity Read ↗

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.Semantic proximity Read ↗

Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.Semantic proximity Read ↗

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