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Article

Genetic Evidence for a Neuroimmune Model of Schizophrenia.

Biological psychiatry - 1 Jun 2026

van der Walt Kristien, Stein Dan J, Zoghbi Anthony W

Abstract excerpt

Since the early 1900s, clinical and epidemiological observations have suggested a link between schizophrenia and the immune system, yet genetic evidence for a pathophysiological connection has remained elusive. Here, we review evidence for immune involvement from a variety of genetic studies to characterize the contribution of genetic variation in immune genes and pathways to schizophrenia risk. Across studies,...

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PMID: 41237892
DOI: 10.1016/j.biopsych.2025.10.038

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CD4

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