Genetic Evidence for a Neuroimmune Model of Schizophrenia.

doi:10.1016/j.biopsych.2025.10.038

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Article

Genetic Evidence for a Neuroimmune Model of Schizophrenia.

Biological psychiatry - 1 Jun 2026

van der Walt Kristien, Stein Dan J, Zoghbi Anthony W

Abstract excerpt

Since the early 1900s, clinical and epidemiological observations have suggested a link between schizophrenia and the immune system, yet genetic evidence for a pathophysiological connection has remained elusive. Here, we review evidence for immune involvement from a variety of genetic studies to characterize the contribution of genetic variation in immune genes and pathways to schizophrenia risk. Across studies,...

Topics

Schizophrenia
Humans
Neuroimmunomodulation
Genetic Predisposition to Disease
Animals

Source

Open in PubMed

Identifiers

PMID: 41237892
DOI: 10.1016/j.biopsych.2025.10.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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