Article

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

2020-08-24

Abstract excerpt

<h4>SUMMARY</h4> Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined, but could be direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms and cardio-protective drugs, we use a state-of-the-art pipeline combining human cardiac organoids with phosphoproteomics and single nuclei RNA sequencing. We identify an inflammat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 643caf43-aba8-5f31-af61-a6f5a1b952a1
DOI: 10.1101/2020.08.23.258574

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)DOI 10.1101/2020.08.23.258574Read

Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 InfectionSemantic proximity Read

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heartSemantic proximity Read

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patientsSemantic proximity Read

Single-nucleus lung transcriptomics and inflammatory responses in lethal COVID-19 reveal potential drugs in advanced-stage clinical trialsSemantic proximity Read

Cardiac SARS-CoV-2 infection is associated with distinct transcriptomic changes within the heartSemantic proximity Read

Necroptosis Drives Major Adverse Cardiovascular Events During Severe COVID-19Semantic proximity Read

Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac InjuriesSemantic proximity Read

Genes Encoding ACE2, TMPRSS2 and Related Proteins Mediating SARS-CoV-2 Viral Entry are Upregulated with Age in Human CardiomyocytesSemantic proximity Read

Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditisSemantic proximity Read

Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonismSemantic proximity Read

Single-cell Transcriptome Analysis Indicates New Potential Regulation Mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2Semantic proximity Read

Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patientsSemantic proximity Read