Article
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Basic research in cardiology - 12 Jun 2020
Lubos Nadine, van der Gaag Svenja, Gerçek Muhammed, Kant Sebastian, Leube Rudolf E, Krusche Claudia A
Abstract excerpt
Arrhythmogenic cardiomyopathy (AC) is an incurable genetic disease, whose pathogenesis is poorly understood. AC is characterized by arrhythmia, fibrosis, and cardiodilation that may lead to sudden cardiac death or heart failure. To elucidate AC pathogenesis and to design possible treatment strategies of AC, multiple murine models have been established. Among them, mice carrying desmoglein 2 mutations are...
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