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Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

2025-07-22

Abstract excerpt

Genetic studies of human embryonic morphogenesis are constrained by ethical and practical challenges, restricting insights into developmental mechanisms and disorders. Human pluripotent stem cell (hPSC)–derived organoids provide a powerful alternative for the study of embryonic morphogenesis. However, screening for genetic drivers of morphogenesis in vitro has been infeasible due to organoid variability and the h...

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Literature Corpus work
4d863df6-64b6-5c1f-b04c-36b404bcda90
DOI
10.1101/2025.07.21.665862
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Arrayed single-gene perturbations identify drivers of human anterior neural tube closureDOI 10.1101/2025.07.21.665862
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