Article

Spatio-temporal, optogenetic control of gene expression in organoids

2021-09-26

Abstract excerpt

Organoids derived from stem cells become increasingly important to study human development and to model disease. However, methods are needed to control and study spatio-temporal patterns of gene expression in organoids. To this aim, we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes, at single-cell resolution and in programmable spatio-temporal patterns. To il...

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Literature Corpus work: acbd1a01-921d-5988-81b2-51aa0b5d39bc
DOI: 10.1101/2021.09.26.461850

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