Article

FBXW11 Activity Regulates Radial Glial Expansion in Human Cerebral Organoids

2026-08-21

Abstract excerpt

Human brain development depends on tightly coordinated gene-regulatory programs and the emergence of complex tissue architecture, making large scale functional interrogation difficult using conventional screen models. To overcome this challenge, we used a pooled CRISPR screening approach. Guided by neuro-specific whole-genome screens in Drosophila, we tested 129 poorly characterised human orthologs and found 8 tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28958d3d-b455-543a-ba46-07d021f3b6d6
DOI: 10.64898/2026.08.20.746070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FBXW11 Activity Regulates Radial Glial Expansion in Human Cerebral OrganoidsDOI 10.64898/2026.08.20.746070Read

A human-specific enhancer fine-tunes radial glia potency and corticogenesisSemantic proximity Read

Single-cell brain organoid screening identifies developmental defects in autismSemantic proximity Read

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size.Semantic proximity Read

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolutionSemantic proximity Read

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.Semantic proximity Read

FBXW7-Related Neurodevelopmental Disorder: Clinical Spectrum, Molecular Mechanisms, and Tumor Predisposition.Semantic proximity Read

Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromesSemantic proximity Read

Regulatory logic of human cortex evolution by combinatorial perturbationsSemantic proximity Read

Integrating molecular studies and clinical disease models to provide mechanistic insight into neurodevelopment: guidance from FOXG1 syndrome.Semantic proximity Read

WNT/β-catenin dependant alteration of cortical neurogenesis in a human stem cell model of SETBP1 disorderSemantic proximity Read

A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disordersSemantic proximity Read

Cerebral Organoids Containing an <i>AUTS2</i> Missense Variant Model MicrocephalySemantic proximity Read