Article

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

2022-06-29

Abstract excerpt

CD4 + T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on MHC-II molecules. The high polymorphism of MHC-II genes represents an important hurdle towards accurate prediction and identification of CD4 + T-cell epitopes in different individuals and different species. Here we collected and curated a dataset of 627,013 unique MHC-II ligands identified by...

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Literature Corpus work: 4d6542c6-7674-5613-a593-ebc29a92642f
DOI: 10.1101/2022.06.26.497561

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