Article

A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 <sup>+</sup> T cells

2025-06-09

Abstract excerpt

CD4 + T cells play a pivotal role in adaptive immunity, recognizing peptide antigens presented by MHC II molecules during infections and tumor development. Identifying immunodominant MHC II epitopess is essential for understanding CD4 + T cell responses; however, current methods such as mass spectrometry, suffer from low sensitivity and throughput, while computational algorithms show variable accuracy. To overco...

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Literature Corpus work: d2a52128-a1da-5c12-a4b0-0b24c80319fb
DOI: 10.1101/2025.06.05.658000

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