Article
Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.
Immunity - 13 Jun 2023
Racle Julien, Guillaume Philippe, Schmidt Julien, Michaux Justine, Larabi Amédé, Lau Kelvin, Perez Marta A S, Croce Giancarlo, Genolet Raphaël, Coukos George, Zoete Vincent, Pojer Florence, Bassani-Sternberg Michal, Harari Alexandre, Gfeller David
Abstract excerpt
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on class II major histocompatibility complex (MHC-II) molecules. The high polymorphism of MHC-II genes represents an important hurdle toward accurate prediction and identification of CD4+ T cell epitopes. Here we collected and curated a dataset of 627,013 unique MHC-II ligands identified by mass...
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