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Article

Predicting MHC-I ligands across alleles and species: how far can we go?

Genome medicine - 20 Mar 2025

Tadros Daniel M, Racle Julien, Gfeller David

Abstract excerpt

BACKGROUND: CD8+ T-cell activation is initiated by the recognition of epitopes presented on class I major histocompatibility complex (MHC-I) molecules. Identifying such epitopes is useful for molecular understanding of cellular immune responses and can guide the development of personalized vaccines for various diseases including cancer. For a few hundred common human and mouse MHC-I alleles, large datasets of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40114147
DOI: 10.1186/s13073-025-01450-8
PMCID: PMC11927126

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