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Article

BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.

Blood - 4 Aug 2016

Wu Song, Li Zongdong, Gnatenko Dmitri V, Zhang Beibei, Zhao Lu, Malone Lisa E, Markova Nedialka, Mantle Timothy J, Nesbitt Natasha M, Bahou Wadie F

Abstract excerpt

Human blood cell counts are tightly maintained within narrow physiologic ranges, largely controlled by cytokine-integrated signaling and transcriptional circuits that regulate multilineage hematopoietic specification. Known genetic loci influencing blood cell production account for <10% of platelet and red blood cell variability, and thrombopoietin/cellular myeloproliferative leukemia virus liganding is...

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Identifiers

PMID: 27207795
DOI: 10.1182/blood-2016-02-696997
PMCID: PMC4974201

Genes

BLVRB

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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