Article

CYB5R3 Controls Sex-Specific Stress Erythropoiesis via Heme-Biosynthesis

2025-12-05

Abstract excerpt

Cytochrome b5 reductase 3 (CYB5R3) or met-hemoglobin reductase is an oxidoreductase that maintains hemoprotein and cellular redox balance, yet its contribution to erythropoiesis under stress conditions remains unclear. Motivated by prior observations that the hypomorphic CYB5R3 T117S blunts hydroxyurea-induced fetal hemoglobin responses in patients with sickle cell disease, we tested whether CYB5R3 contributes to...

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Literature Corpus work: c91f2924-b9d3-5fed-a823-445155e32580
DOI: 10.64898/2025.12.04.692104

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