Article

Astrocytic lactate shuttle disruption and the energy-starved lysosome in Alzheimer's disease

2026-07-15

Abstract excerpt

<title>Abstract</title> <p> Lysosomal dysfunction is central to Alzheimer’s disease (AD), yet why structurally intact vacuolar H⁺-ATPase (V-ATPase) proton pumps fail to maintain lysosomal pH remains unresolved. Because V-ATPase activity depends on continuous ATP supply, we hypothesized that disruption of the astrocyte–neuron lactate shuttle imposes a cross-cellular energy deficit—an <bold>“energy-starved lysoso...

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Literature Corpus work: 4d3c1ea0-930f-59c5-859f-dbc06a4b1cb0
DOI: 10.21203/rs.3.rs-10057949/v1

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