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Single-Nucleus Phosphatome Rewiring and Phosphoproteomics Reveal PFKFB2 as an LRRK2-Linked Metabolic Node in Human Parkinsonian Substantia Nigra

2026-06-10

Abstract excerpt

Aberrant signalling by leucine-rich repeat kinase 2 (LRRK2) is a major driver of Parkinson’s disease (PD) biology, linking Rab phosphorylation to vesicular trafficking, endolysosomal dysfunction and immune-cell regulation. However, how LRRK2-linked trafficking programs intersect with metabolic and mitochondrial remodeling within vulnerable human substantia nigra cell states remains poorly defined. Here, phosphatom...

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Literature Corpus work
0b9fe390-2e11-5b9b-9f82-e6c600369202
DOI
10.20944/preprints202606.0752.v1
Open publication

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Single-Nucleus Phosphatome Rewiring and Phosphoproteomics Reveal PFKFB2 as an LRRK2-Linked Metabolic Node in Human Parkinsonian Substantia NigraDOI 10.20944/preprints202606.0752.v1
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