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Astrocyte subtype-specific expression of the sodium-coupled citrate transporter SLC13A5 and citrate metabolism genes across Alzheimer’s disease pseudoprogression: a single-nucleus RNA sequencing analysis of the human middle temporal gyrus

2026-06-08

Abstract excerpt

The sodium-coupled citrate transporter NaCT (SLC13A5) imports extracellular citrate into cells. In the CNS, SLC13A5 is described to be expressed predominantly in neurons. Cytosolic citrate levels rely on citrate generated in mitochondria and imported from other CNS cells, regulating intermediary metabolism and supplying acetyl-CoA for lipid synthesis and histone acetylation. Despite evidence for NaCT’s role in neu...

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Literature Corpus work: efc9ed6d-de33-5d24-8c87-d518512d76dc
DOI: 10.64898/2026.06.05.730472

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