Article
Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2016
Roses Allen, Sundseth Scott, Saunders Ann, Gottschalk William, Burns Dan, Lutz Michael
Abstract excerpt
The methodology of Genome-Wide Association Screening (GWAS) has been applied for more than a decade. Translation to clinical utility has been limited, especially in Alzheimer's Disease (AD). It has become standard practice in the analyses of more than two dozen AD GWAS studies to exclude the apolipoprotein E (APOE) region because of its extraordinary statistical support, unique thus far in complex human diseases....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.