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Article

Detrimental Effects of Apolipoprotein E4: Potential Therapeutic Targets in Alzheimers Disease

1 Dec 2007

Abstract excerpt

As the major genetic risk factor for Alzheimer's disease, the apolipoprotein (apo) E4 isoform is a promising therapeutic target. ApoE4 likely contributes to Alzheimer's disease pathology by interacting with multiple factors through various pathways. Interactions with the amyloid beta peptide and the amyloid cascade, for example, may lead to cognitive decline and neurodegeneration. Alternatively, apoE4 might act...

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PMID: 18220516
DOI: 10.2174/156720507783018334

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