Article

Genetic background influences MAFA <sup>S64F</sup> -mediated diabetes penetrance in male mice

2025-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic β-cells require the coordinated expression of transcription factors such as MAFA to dynamically secrete insulin to maintain euglycemia. A naturally occurring mutation in MAFA (MAFA S64F ) produces a long-lived variant protein which predisposes carriers to dichotomous conditions of either maturity (adult)-onset diabetes of the young (MODY) or hypoglycemia in a sex-dependent manner. He...

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Literature Corpus work: 4d316ea8-96b5-58a4-96a6-a91c199bee7b
DOI: 10.1101/2025.05.20.653758

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