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Article

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure

12 Feb 2025

Abstract excerpt

Androgen exposure (AE) poses a profound health threat to women, yet its transgenerational impacts on male descendants remain unclear. Here, employing a large-scale mother-child cohort, we show that maternal hyperandrogenism predisposes sons to β-cell dysfunction. Male offspring mice with prenatal AE exhibited hyperglycemia and glucose intolerance across three generations, which were further exacerbated by aging...

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PMID: 39934105
DOI: 10.1038/s41421-025-00769-1

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