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Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODY

2025-04-15

Abstract excerpt

<title>Abstract</title> <p>Heterozygous mutations in <italic>HNF1A</italic> cause HNF1A-MODY, the most common form of monogenic diabetes, characterized by age-dependent onset and progression. Despite <italic>HNF1A</italic>'s established role in beta cell function, the mechanisms underlying disease progression remain poorly understood, with conventional mouse models failing to recapitulate the gradual metabolic de...

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Literature Corpus work: 4dc7f04d-1621-5e72-ad96-e738735ebb70
DOI: 10.21203/rs.3.rs-6369014/v1

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