Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

doi:10.1186/1471-2164-14-248

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Article

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

BMC genomics - 15 Apr 2013

Tanisawa Kumpei, Mikami Eri, Fuku Noriyuki, Honda Yoko, Honda Shuji, Ohsawa Ikuro, Ito Masafumi, Endo Shogo, Ihara Kunio, Ohno Kinji, Kishimoto Yuki, Ishigami Akihito, Maruyama Naoki, Sawabe Motoji, Iseki Hiroyoshi, Okazaki Yasushi, Hasegawa-Ishii Sanae, Takei Shiro, Shimada Atsuyoshi, Hosokawa Masanori, Mori Masayuki, Higuchi Keiichi, Takeda Toshio, Higuchi Mitsuru, Tanaka Masashi

Abstract excerpt

BACKGROUND: Senescence-accelerated mice (SAM) are a series of mouse strains originally derived from unexpected crosses between AKR/J and unknown mice, from which phenotypically distinct senescence-prone (SAMP) and -resistant (SAMR) inbred strains were subsequently established. Although SAMP strains have been widely used for aging research focusing on their short life spans and various age-related phenotypes, such...

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PMID: 23586671
DOI: 10.1186/1471-2164-14-248
PMCID: PMC3637625

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