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Article

The Genetic Landscape of Type 2 Diabetes in Mice

1 Feb 2007

Abstract excerpt

Inbred mouse strains provide genetic diversity comparable to that of the human population. Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains differ in the response of their critical physiological functions, such as insulin sensitivity, insulin secretion, beta-cell proliferation and survival, and fuel partitioning, to diet and obesity. Most of the critical genes...

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PMID: 17018838
DOI: 10.1210/er.2006-0035

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