Article

DL-PRS: a novel deep learning approach to polygenic risk scores

2021-04-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>COPD is a complex heterogeneous disease influenced by both environmental and genetic risk factors. Traditional genome wide association studies (GWAS) have been successful in identifying many reproducible risk variants of moderate to small effect. Polygenic risk scores (PRS) were developed as way to aggregate risk alleles weighted by their effect size to produce a...

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Literature Corpus work: 4d12dc02-cbec-5ffc-a4c3-7389a1852b2f
DOI: 10.21203/rs.3.rs-423764/v1

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