Article
Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.
Nature genetics - 1 May 2023
Cosentino Justin, Behsaz Babak, Alipanahi Babak, McCaw Zachary R, Hill Davin, Schwantes-An Tae-Hwi, Lai Dongbing, Carroll Andrew, Hobbs Brian D, Cho Michael H, McLean Cory Y, Hormozdiari Farhad
Abstract excerpt
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, is highly heritable. While COPD is clinically defined by applying thresholds to summary measures of lung function, a quantitative liability score has more power to identify genetic signals. Here we train a deep convolutional neural network on noisy self-reported and International Classification of Diseases labels to predict...
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