Article

Polygenic risk scores enhance the identification of carriers of monogenic forms of idiopathic pulmonary fibrosis

2026-04-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Idiopathic pulmonary fibrosis (IPF) is a rare disease with a poor prognosis. Disease risk involves rare and common genetic variants. However, an inverse association have been described between them. Accordingly, IPF patients with a higher polygenic risk score (PRS) for IPF are less likely to carry rare deleterious variants and vice versa. Here, we evaluate weather PRS of IPF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 666a9233-ba53-5838-b1ee-418369b22619
DOI: 10.64898/2026.04.16.26350967

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk scores enhance the identification of carriers of monogenic forms of idiopathic pulmonary fibrosisDOI 10.64898/2026.04.16.26350967Read

A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.Semantic proximity Read

Rare variants and survival of patients with idiopathic pulmonary fibrosisSemantic proximity Read

Mapping the common and rare variant genetic risk landscape for pulmonary fibrosis, with and without family historySemantic proximity Read

Polygenic Risk and Rare Variants in Endotypes of Idiopathic Pulmonary FibrosisSemantic proximity Read

Rare variants and survival of patients with idiopathic pulmonary fibrosis: analysis of a multicentre, observational cohort study with independent validation.Semantic proximity Read

Contribution of dominant and recessive model effects to the genetic architecture of Idiopathic Pulmonary FibrosisSemantic proximity Read

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case-control cohorts.Semantic proximity Read

Polygenic risk score and clinical factors predict incident idiopathic pulmonary arterial hypertension.Semantic proximity Read

Common single nucleotide polymorphisms associated with idiopathic pulmonary fibrosis: a systematic review.Semantic proximity Read

Utility of polygenic risk scores in diagnostic genetic testing for dilated cardiomyopathySemantic proximity Read

Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary FibrosisSemantic proximity Read

Genetics in Idiopathic Pulmonary Fibrosis Pathogenesis, Prognosis, and TreatmentSemantic proximity Read