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Article

Modeling gene interactions in polygenic prediction via geometric deep learning.

Genome research - 22 Jan 2025

Li Han, Zeng Jianyang, Snyder Michael P, Zhang Sai

Abstract excerpt

Polygenic risk score (PRS) is a widely used approach for predicting individuals' genetic risk of complex diseases, playing a pivotal role in advancing precision medicine. Traditional PRS methods, predominantly following a linear structure, often fall short in capturing the intricate relationships between genotype and phenotype. In this study, we present PRS-Net, an interpretable geometric deep learning-based...

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Identifiers

PMID: 39562137
DOI: 10.1101/gr.279694.124
PMCID: PMC11789630

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