Article

DROP-DEEP: Dimensionality Reduction for Polygenic Risk Score Using Deep Learning Approach

2024-05-02

Abstract excerpt

<h4>Motivation</h4> Advances in sequencing technologies have enabled the early detection of genetic diseases and the development of personalized medicine. However, the variance explained by genetic variations is typically small compared to the heritability estimates. Consequently, there is a pressing need to develop enhanced polygenic risk score (PRS) prediction models. We seek an approach that transcends the limi...

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Literature Corpus work: 62272476-d62e-555d-b69a-e3ea3508ee68
DOI: 10.1101/2024.05.01.24306609

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