Article

SNPRS:Stacked Neural network for predicting Polygenic Risk Score

2023-07-12

Abstract excerpt

In recent years, polygenic risk scores (PRS) have increasingly been used to predict disease susceptibility from genome-wide association studies (GWAS) outcomes. However, these models are limited by overfitting and potential overestimation of the effect size of correlated variants. To address these issues, this study presents a novel Stacked Neural Network Polygenic Risk Score (SNPRS) approach. SNPRS combines outpu...

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Literature Corpus work: 4e556e18-2c55-56dc-8f5f-963a6a397b06
DOI: 10.21203/rs.3.rs-3076268/v1

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