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Article

Deep learning and statistical methods identify novel asthma risk variants in Europeans.

The Journal of allergy and clinical immunology - 1 Jul 2026

Chen Enguo, Jiang Yue, Meng Ziang, Song Yingchao, Wang Xianjin, Wu Qinfeng, Yang Yujuan, Zhang Yu, Glessner Joseph, Song Xicheng, Hakonarson Hakon, Chang Xiao

Abstract excerpt

BACKGROUND: Asthma is a common heritable respiratory disorder with a complex genetic basis. Although large-scale genome-wide association studies have identified many risk loci, the full spectrum of its polygenic architecture remains to be defined. OBJECTIVE: We refined the genetic landscape of asthma in individuals of European ancestry and improve polygenic risk prediction through statistical and deep...

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Identifiers

PMID: 41932550
DOI: 10.1016/j.jaci.2026.03.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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