Article

MTCH2 is a mitochondrial outer membrane protein insertase

2022-09-16

Abstract excerpt

In the mitochondrial outer membrane, tail-anchored (TA) proteins play critical roles in cytoplasmic-mitochondrial communication. Using genome-wide CRISPRi screens, we identify factors involved in mitochondrial TA biogenesis in human cells. We show that MTCH2, and its paralog MTCH1, are required for insertion of biophysically diverse mitochondrial TAs, but not outer membrane β-barrel proteins. In a reconstituted sy...

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Literature Corpus work: 4d045613-ba39-57d6-b7b0-7cdf5e2e4979
DOI: 10.1101/2022.09.15.508165

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