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Mitochondrial CHCHD2 and CHCHD10: Roles in Neurological Diseases and Therapeutic Implications

16 Sept 2019

Abstract excerpt

mutations have been identified in various neurological diseases such as Parkinson's disease (PD), frontotemporal dementia (FTD), and Alzheimer's disease (AD). It is also the first mitochondrial gene whose mutations lead to PD. CHCHD10 is a homolog of CHCHD2; similar to CHCHD2, various mutations of CHCHD10 have been identified in a broad spectrum of neurological disorders, including FTD and AD, with a high...

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PMID: 31526091
DOI: 10.1177/1073858419871214

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