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Inhibition of Mitochondrial Carrier Homolog 2 (MTCH2) Suppresses Tumor Invasion and Enhances Sensitivity to Temozolomide in Malignant Glioma

2020-12-31

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells and decrease mitochondria-dependent cell death. However, the underlying mechanism for mitochondrial dysfunction in glioma is not well elucidated. MTCH2 is...

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Literature Corpus work
92b2c5c5-9b34-5c7d-9e84-b699fc6c6bf9
DOI
10.21203/rs.3.rs-53540/v3
Open publication

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Inhibition of Mitochondrial Carrier Homolog 2 (MTCH2) Suppresses Tumor Invasion and Enhances Sensitivity to Temozolomide in Malignant GliomaDOI 10.21203/rs.3.rs-53540/v3
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