Article

A multiplexed approach for genetic screening of human cells by electron microscopy uncovers a critical effector of mitochondrial cristae shape

2025-11-16

Abstract excerpt

Mitochondria form complex and diverse membrane-architectures essential for their multiple functions. Whereas critical proteins sculpting mitochondrial membranes have been identified, the molecular basis for many key features remains enigmatic. Exploration of membrane ultrastructure, in general, is limited by the tradeoff between resolution and throughput: electron microscopy (EM) is essential to resolve their ultr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e12c1be5-9da6-599a-8db5-11334daa80f9
DOI: 10.1101/2025.11.15.688601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multiplexed approach for genetic screening of human cells by electron microscopy uncovers a critical effector of mitochondrial cristae shapeDOI 10.1101/2025.11.15.688601Read

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s diseaseSemantic proximity Read

A genome-wide atlas of human cell morphologySemantic proximity Read

Pathogenic Morphological Signatures of Perturbations in Mitochondrial-Related Genes Revealed by Pooled Imaging AssaySemantic proximity Read

Disease phenotyping: structural and functional readouts.Semantic proximity Read

Integrative structure determination of a human mitochondrial contact site and cristae organizing system (MICOS) sub-assemblySemantic proximity Read

Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics ScreenSemantic proximity Read

MTCH2 is a mitochondrial outer membrane protein insertaseSemantic proximity Read

Multimodal cell maps as a foundation for structural and functional genomics.Semantic proximity Read

Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical Phenotype.Semantic proximity Read

Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations.Semantic proximity Read

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neuronsSemantic proximity Read

A scalable screening platform for phenotypic subtyping of ALS patient-derived fibroblastsSemantic proximity Read