Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

28 Jan 2021

Abstract excerpt

BACKGROUND: Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells and decrease mitochondria-dependent cell death. However, the underlying mechanism for mitochondrial dysfunction in glioma is not well elucidated. MTCH2 is a mitochondrial outer membrane protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glioma Diagnosis and Treatment
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33509092
DOI: 10.1186/s10020-020-00261-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant gliomaPMID 33509092Read ↗

Inhibition of Mitochondrial Carrier Homolog 2 (MTCH2) Suppresses Tumor Invasion and Enhances Sensitivity to Temozolomide in Malignant GliomaSemantic proximity Read ↗

Molecular insights into glioblastoma progression: role of CHCHD2P9 in tumor heterogeneity and prognosisSemantic proximity Read ↗

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistanceSemantic proximity Read ↗

TMEM2 Combined with IDH and 1p19q in Refining Molecular Subtypes for Predicting Survival of Patients with Glioma.Semantic proximity Read ↗

MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and ReproductionSemantic proximity Read ↗

Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patientsSemantic proximity Read ↗

PSMC2 is overexpressed in glioma and promotes proliferation and anti-apoptosis of glioma cellsSemantic proximity Read ↗

<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span style="mso-bidi-font-size: 18.0pt;">A Coordinated Mitochondrial Genome Program Predicts Improved Outcome in Lower-Grade GliomaSemantic proximity Read ↗

Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancerSemantic proximity Read ↗

Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy.Semantic proximity Read ↗

MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolismSemantic proximity Read ↗

MTFR2-dependent mitochondrial fission promotes HCC progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.